Assay Detail
Binding
CHEMBL5657213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type Flag-tagged human PRMT3 catalytic activity transfected in HEK293 cells assessed as inhibition of exogenous GFP-tagged H4R3 asymmetric dimethylation incubated for 24 hrs by Western blot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 3 (CHEMBL5891) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.04 | 7.04 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0008116 |
| EFO_ID | EFO_ID | - | — | EFO:0001645 |
| EFO_TERM | EFO_TERM | - | — | oculopharyngeal muscular dystrophy |
| EFO_TERM | EFO_TERM | - | — | coronary artery disease |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072005 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072005 | — | IC50 | = | 91.0 | nM | 7.04 |