Assay Detail
Functional
CHEMBL5657550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MEXF1341 cells harboring NRAS Q61 mutation assessed as reduction in cell viability incubated for 72 hrs by CellTitre-Glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MEXF1341 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.02 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362558 | LY-2090314 | 2.0 | 1 | 8.10 |
| CHEMBL430226 | 6-BROMOINDIRUBIN-3'-ACETOXIME | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362558 | LY-2090314 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL430226 | 6-BROMOINDIRUBIN-3'-ACETOXIME | IC50 | = | 1148.0 | nM | 5.94 |