Assay Detail
Functional
CHEMBL5657551
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Antiproliferative activity against human MEXF1792 cells harboring NRAS G13D mutation assessed as reduction in cell viability incubated for 72 hrs by CellTitre-Glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MEXF1792 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.33 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362558 | LY-2090314 | 2.0 | 1 | 7.34 |
| CHEMBL430226 | 6-BROMOINDIRUBIN-3'-ACETOXIME | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362558 | LY-2090314 | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL430226 | 6-BROMOINDIRUBIN-3'-ACETOXIME | IC50 | = | 4939.0 | nM | 5.31 |