Assay Detail
Functional
CHEMBL5657580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human vemurafenib-resistant M14 cells harboring BRAF V600E mutation assessed as reduction in cell viability incubated for 72 hrs by CellTitre-Glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M14 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.78 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL362558 | LY-2090314 | 2.0 | 1 | 8.15 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL362558 | LY-2090314 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 3856.0 | nM | 5.41 |