Assay Detail
Functional
CHEMBL5658130
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on DISC1 knockdown-elicited synaptic changes in rat cortical neurons assessed as prevention of spine size reduction preincubated for 60 mins followed by APV WD solution addition and measured after 20 mins by immunofluorescence analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Cortical neurone |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3609326 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3609326 | — | EC50 | = | 500.0 | nM | 6.30 |