Assay Detail
Binding
CHEMBL5658247
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Inhibition of JAK1 (unknown origin) in presence of ATP by radiometric assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.87 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 9.30 |
| CHEMBL4128410 | — | — | 1 | 7.72 |
| CHEMBL4564280 | — | — | 1 | 7.28 |
| CHEMBL5188882 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | IC50 | = | 0.496 | nM | 9.30 |
| CHEMBL4128410 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4564280 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5188882 | — | IC50 | = | 64.0 | nM | 7.19 |