Assay Detail
Functional
CHEMBL5659660
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of autophagy in human U2OS cells assessed as BafA1-induced LC3B-II accumulation preincubated with compound for 3 hrs and followed by BafA1 induction and measured after 1.5 hrs by immunoblotting analysis
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.16 | 6.16 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744680 | — | — | 2 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744680 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4744680 | — | Inhibition | - | % | - |