Assay Detail
Functional
CHEMBL5659670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H2030 cells harboring KRAS G12C mutant assessed as reduction in cell viability pretreated with compound for 2 days under full growth media condition followed by replaced drug-free full growth media for 5 days by celltiter-glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2030 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 4.69 | 4.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744680 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744680 | — | EC50 | = | 20300.0 | nM | 4.69 |