Assay Detail
Functional
CHEMBL5659675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A549 cells harboring KRAS G12S mutant assessed as reduction in cell viability pretreated with compound for 2 days under optistarve condition followed by replaced drug-free full growth media for 5 days by celltiter-glo assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4744680 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4744680 | — | EC50 | = | 10000.0 | nM | 5.00 |