Assay Detail
Binding
CHEMBL5665134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EML4-ALK (unknown origin) expressed in mouse 3T3 cells assessed as growth inhibition measured after 2 days by celltiter-glo luminescent cell viability assay
4
Total Activities
2
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI | 2 | - | - |
| IC50 | 2 | 7.37 | 7.38 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0003060 |
| EFO_TERM | EFO_TERM | - | — | non-small cell lung carcinoma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545360 | ASP-3026 | 1.0 | 2 | 7.38 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 2 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545360 | ASP-3026 | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3545360 | ASP-3026 | GI | - | — | - | |
| CHEMBL601719 | CRIZOTINIB | GI | - | — | - |