Assay Detail
Functional
CHEMBL5675604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KG-1a cells assessed as decrease in cell viability measured after 24 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KG-1a |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.29 | 9.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1089316 | CHAETOCIN | — | 1 | 9.99 |
| CHEMBL1231795 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1089316 | CHAETOCIN | IC50 | = | 0.103 | nM | 9.99 |
| CHEMBL1231795 | — | IC50 | = | 26530.0 | nM | 4.58 |