Assay Detail
Functional
CHEMBL5675787
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Cytotoxicity against human OVCAR-3 cells assessed as reduction in cell viability after 3 days by XTT assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 7.92 |
| IC25 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3544911 | PREXASERTIB | 2.0 | 2 | 7.92 |
| CHEMBL1957266 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3544911 | PREXASERTIB | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1957266 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3544911 | PREXASERTIB | IC25 | = | 6.0 | nM | - |