Assay Detail

CHEMBL5683016

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Binding

Inhibition of human recombinant JAK1 incubated for 60 mins

ChEMBL ↗

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Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Open DB target context

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Tyrosine-protein kinase JAK1 (CHEMBL2835) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase JAK1

CHEMBL2835

Anchored from Assay target.

Protein identity Tyrosine-protein kinase JAK1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.

Van Rompaey L, Galien R, van der Aar EM, Clement-Lacroix P, Nelles L, Smets B, Lepescheux L, Christophe T, Conrath K, Vandeghinste N, Vayssiere B, De Vos S, Fletcher S, Brys R, van 't Klooster G, Feyen JH, Menet C.
J Immunol (2013) 191 : 3568 -3577
PubMed 24006460 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.00	8.00

Assay Parameters

Parameter	Type	Value	Units	Text
EFO_ID	EFO_ID	-	—	EFO:0005140
EFO_ID	EFO_ID	-	—	HP:0001370
EFO_TERM	EFO_TERM	-	—	autoimmune disease
EFO_TERM	EFO_TERM	-	—	rheumatoid arthritis

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3301607	FILGOTINIB	4.0	1	8.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3301607	FILGOTINIB	IC50	=	10.0	nM	8.00