Assay Detail
Binding
CHEMBL5683020
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Binding affinity to human recombinant JAK1 assessed as dissociation constant by Cheng-Prusoff equation analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 7.96 | 7.96 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0005140 |
| EFO_ID | EFO_ID | - | — | HP:0001370 |
| EFO_TERM | EFO_TERM | - | — | autoimmune disease |
| EFO_TERM | EFO_TERM | - | — | rheumatoid arthritis |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301607 | FILGOTINIB | 4.0 | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301607 | FILGOTINIB | Kd | = | 11.0 | nM | 7.96 |