Assay Detail
Binding
CHEMBL5684252
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Inhibition of PAK4 (unknown origin)
5
Total Activities
5
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PAK 4 (CHEMBL4482) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of p21-activated kinases (PAKs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.49 | 7.72 |
| Ki | 1 | 5.62 | 5.62 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3128043 | PF-03758309 | 1.0 | 1 | 7.72 |
| CHEMBL3609326 | — | — | 1 | 6.11 |
| CHEMBL3799807 | — | — | 1 | 6.10 |
| CHEMBL5687057 | — | — | 1 | 6.02 |
| CHEMBL3770186 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3128043 | PF-03758309 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3609326 | — | IC50 | = | 779.0 | nM | 6.11 |
| CHEMBL3799807 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5687057 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3770186 | — | Ki | = | 2400.0 | nM | 5.62 |