Assay Detail
Binding
CHEMBL5685871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat GPR52 expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 30 mins by Alphascreen assay
1
Total Activities
1
Compounds Tested
1
Activity Types
6
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
G protein-coupled receptor 52 (CHEMBL6066828) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.87 | 6.87 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0005090 |
| EFO_ID | EFO_ID | - | — | EFO:0000677 |
| EFO_ID | EFO_ID | - | — | HP:0100543 |
| EFO_TERM | EFO_TERM | - | — | schizophrenia |
| EFO_TERM | EFO_TERM | - | — | mental or behavioural disorder |
| EFO_TERM | EFO_TERM | - | — | cognitive impairment |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082756 | TP-024 | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082756 | TP-024 | EC50 | = | 134.9 | nM | 6.87 |