Assay Detail
Functional
CHEMBL5696926
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NOMO-1 cells harboring MLL-AF9 assessed as inhibition of cell growth incubated for 4 hrs by CellTiter-Aqueous One assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NOMO-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2017291 | — | — | 1 | 7.82 |
| CHEMBL495727 | AT-9283 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2017291 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL495727 | AT-9283 | IC50 | > | 10000.0 | nM | - |