Assay Detail

CHEMBL5700782

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Binding

Inhibition of SSB (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis

ChEMBL ↗

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Target

Lupus La protein (CHEMBL2040701) ↗

Open DB target context

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Lupus La protein (CHEMBL2040701) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Lupus La protein

CHEMBL2040701

Anchored from Assay target.

Protein identity Lupus La protein

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Lupus La protein (CHEMBL2040701) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T.
Nature (2011) 478 : 529 -533
PubMed 21964340 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.00	8.00

Assay Parameters

Parameter	Type	Value	Units	Text
EFO_ID	EFO_ID	-	—	EFO:0000565
EFO_TERM	EFO_TERM	-	—	leukemia

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1232461	MOLIBRESIB	2.0	1	8.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1232461	MOLIBRESIB	IC50	=	10.0	nM	8.00