Assay Detail

CHEMBL5701043

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Binding

Inhibition of PNN (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis

ChEMBL ↗

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Target

Pinin (CHEMBL5725146) ↗

Open DB target context

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Primary target Pinin

CHEMBL5725146

Anchored from Assay target.

Protein identity Pinin

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Pinin (CHEMBL5725146) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T.
Nature (2011) 478 : 529 -533
PubMed 21964340 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.00	8.00

Assay Parameters

Parameter	Type	Value	Units	Text
EFO_ID	EFO_ID	-	—	EFO:0000565
EFO_TERM	EFO_TERM	-	—	leukemia

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1232461	MOLIBRESIB	2.0	1	8.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1232461	MOLIBRESIB	IC50	=	10.0	nM	8.00