Assay Detail
Functional
CHEMBL5706536
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Antiproliferative activity against human CHRF-288-11 cells harboring JAK2T875N mutant measured after 72 hrs by Alamar blue staining based analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHRF-288-11 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078178 | MOMELOTINIB | 4.0 | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078178 | MOMELOTINIB | IC50 | = | 1.0 | nM | 9.00 |