Assay Detail

CHEMBL5709458

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human BB3 receptor

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Bombesin receptor subtype-3 (CHEMBL4080) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Bombesin receptor subtype-3 (CHEMBL4080) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Bombesin receptor subtype-3

CHEMBL4080

Anchored from Assay target.

Protein identity Bombesin receptor subtype-3

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Bombesin receptor subtype-3 (CHEMBL4080) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.

Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH.
Proc Natl Acad Sci U S A (2014) 111 : 12853 -12858
PubMed 25136132 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.09	5.09

Assay Parameters

Parameter	Type	Value	Units	Text
EFO_ID	EFO_ID	-	—	MONDO:0004992
EFO_TERM	EFO_TERM	-	—	cancer

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3414622	—	—	1	5.09

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3414622	—	IC50	=	8100.0	nM	5.09