Assay Detail
Binding
CHEMBL5710155
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Binding affinity to BCL-W (unknown origin) assessed as dissociation constant incubated for 1 hrs by TR-FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.59 | 8.70 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5712050 | — | — | 1 | 8.70 |
| CHEMBL3793424 | — | — | 1 | 8.40 |
| CHEMBL3342332 | A-1155463 | — | 1 | 8.10 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.68 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 6.61 |
| CHEMBL4228713 | A-1211212 | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5712050 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3793424 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3342332 | A-1155463 | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL443684 | NAVITOCLAX | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3137309 | VENETOCLAX | Ki | = | 245.0 | nM | 6.61 |
| CHEMBL4228713 | A-1211212 | Ki | = | 852.0 | nM | 6.07 |