Assay Detail
Functional
CHEMBL5710160
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Antiproliferative activity against Bcl-xl dependent human MOLT-4 cells assessed as reduction in cell viability by measuring effect concentration by CellTiter-Glo reagent based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.19 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3793424 | — | — | 1 | 8.22 |
| CHEMBL3342332 | A-1155463 | — | 1 | 7.16 |
| CHEMBL5712050 | — | — | 1 | 6.87 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 6.52 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | - |
| CHEMBL4228713 | A-1211212 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3793424 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3342332 | A-1155463 | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5712050 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL443684 | NAVITOCLAX | EC50 | = | 303.0 | nM | 6.52 |
| CHEMBL3137309 | VENETOCLAX | EC50 | > | 5000.0 | nM | - |
| CHEMBL4228713 | A-1211212 | EC50 | > | 5000.0 | nM | - |