Assay Detail
Functional
CHEMBL5710180
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Antiproliferative activity against human OCI-AML2 assessed as reduction in cell viability incubated for 48 hrs by CellTiter-Glo cell vaibility assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OCI-AML2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.48 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.96 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 7.00 |
| CHEMBL3342332 | A-1155463 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3137309 | VENETOCLAX | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3342332 | A-1155463 | EC50 | > | 5000.0 | nM | - |