Assay Detail

CHEMBL5710508

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Functional

Agonist activity at 5-HT1B receptor (unknown origin)

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 1B (CHEMBL1898) ↗

Open DB target context

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5-hydroxytryptamine receptor 1B (CHEMBL1898) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 1B

CHEMBL1898

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 1B

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

5-hydroxytryptamine receptor 1B (CHEMBL1898) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.

Mohammad HP, Smitheman KN, Kamat CD, Soong D, Federowicz KE, Van Aller GS, Schneck JL, Carson JD, Liu Y, Butticello M, Bonnette WG, Gorman SA, Degenhardt Y, Bai Y, McCabe MT, Pappalardi MB, Kasparec J, Tian X, McNulty KC, Rouse M, McDevitt P, Ho T, Crouthamel M, Hart TK, Concha NO, McHugh CF, Miller WH, Dhanak D, Tummino PJ, Carpenter CL, Johnson NW, Hann CL, Kruger RG.
Cancer Cell (2015) 28 : 57 -69
PubMed 26175415 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	5.30	5.30

Assay Parameters

Parameter	Type	Value	Units	Text
EFO_ID	EFO_ID	-	—	MONDO:0004992
EFO_TERM	EFO_TERM	-	—	cancer

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4301645	—	—	1	5.30
CHEMBL3786182	GSK2879552	1.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4301645	—	EC50	=	5000.0	nM	5.30
CHEMBL3786182	GSK2879552	EC50	>	32000.0	nM	-