Assay Detail
Functional
CHEMBL5711665
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against mouse Ba/F3 EGFR-T790M/L858R cells assessed as inhibition of cell viability incubated for 72 hrs by CellTiter-Glo assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Ba/F3 EGFR-T790M/L858R |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.88 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.39 |
| CHEMBL3787344 | NAZARTINIB | 2.0 | 1 | 7.81 |
| CHEMBL3397300 | — | — | 1 | 7.44 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.41 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 7.27 |
| CHEMBL4203266 | — | — | 1 | 6.73 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.63 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 6.16 |
| CHEMBL3545360 | ASP-3026 | 1.0 | 1 | 5.77 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3787344 | NAZARTINIB | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL3397300 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 39.2 | nM | 7.41 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL4203266 | — | IC50 | = | 184.5 | nM | 6.73 |
| CHEMBL509032 | TAE-684 | IC50 | = | 232.6 | nM | 6.63 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 685.2 | nM | 6.16 |
| CHEMBL3545360 | ASP-3026 | IC50 | = | 1691.0 | nM | 5.77 |
| CHEMBL939 | GEFITINIB | IC50 | = | 5922.0 | nM | 5.23 |