Assay Detail
Functional
CHEMBL5712036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KU-19-19 cells assessed as reduction in cell viability incubated for 5 days by celltiter-glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KU-19-19 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.26 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.14 |
| CHEMBL5712049 | — | — | 1 | 5.78 |
| CHEMBL5712063 | — | — | 1 | 5.64 |
| CHEMBL5712066 | — | — | 1 | 5.51 |
| CHEMBL5712045 | — | — | 1 | 5.26 |
| CHEMBL5712044 | — | — | 1 | 5.22 |
| CHEMBL5712046 | — | — | 1 | 5.19 |
| CHEMBL5712059 | — | — | 1 | 5.17 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.15 |
| CHEMBL5712048 | — | — | 1 | 5.14 |
| CHEMBL4795065 | Borussertib | — | 1 | 5.11 |
| CHEMBL5712055 | — | — | 1 | 4.95 |
| CHEMBL5712042 | — | — | 1 | 4.83 |
| CHEMBL5712058 | — | — | 1 | 4.77 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 4.68 |
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 4.62 |
| CHEMBL5712061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5712049 | — | EC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL5712063 | — | EC50 | = | 2313.0 | nM | 5.64 |
| CHEMBL5712066 | — | EC50 | = | 3055.0 | nM | 5.51 |
| CHEMBL5712045 | — | EC50 | = | 5543.0 | nM | 5.26 |
| CHEMBL5712044 | — | EC50 | = | 6067.0 | nM | 5.22 |
| CHEMBL5712046 | — | EC50 | = | 6442.0 | nM | 5.19 |
| CHEMBL5712059 | — | EC50 | = | 6755.0 | nM | 5.17 |
| CHEMBL1079175 | MK-2206 | EC50 | = | 7054.0 | nM | 5.15 |
| CHEMBL5712048 | — | EC50 | = | 7157.0 | nM | 5.14 |
| CHEMBL4795065 | Borussertib | EC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL5712055 | — | EC50 | = | 11332.0 | nM | 4.95 |
| CHEMBL5712042 | — | EC50 | = | 14942.0 | nM | 4.83 |
| CHEMBL5712058 | — | EC50 | = | 17119.0 | nM | 4.77 |
| CHEMBL2325741 | CAPIVASERTIB | EC50 | = | 20866.0 | nM | 4.68 |
| CHEMBL2177390 | IPATASERTIB | EC50 | = | 24037.0 | nM | 4.62 |
| CHEMBL5712061 | — | EC50 | > | 30000.0 | nM | - |