Assay Detail
Binding
CHEMBL5713487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of amino terminal GST tagged BRD9 (aa 130-259 residues) (unknown origin) expressed in Escherichia coli using biotinylated histone H3 K9/14/18/23Ac (1-28) peptide as substrate incubated for 60 mins by alpha-screen assay
3
Total Activities
3
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 7.89 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0000222 |
| EFO_ID | EFO_ID | - | — | EFO:0000222 |
| EFO_TERM | EFO_TERM | - | — | acute myeloid leukemia |
| EFO_TERM | EFO_TERM | - | — | acute myeloid leukemia |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3824146 | — | — | 1 | 7.89 |
| CHEMBL3823478 | — | — | 1 | 7.68 |
| CHEMBL3823697 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3824146 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3823478 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3823697 | — | IC50 | = | 67.0 | nM | 7.17 |