Assay Detail
Binding
CHEMBL5714832
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Inhibition of IKK in human MCF7 cells assessed as reduction in TNFalpha-induced IkappaBalpha degradation preincubated for 1 hr followed by TNFalpha-stimulation and measured after 30 mins by NanoBiT cell-based immunoassay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A homogeneous bioluminescent immunoassay to probe cellular signaling pathway regulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.84 | 5.84 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200027 | — | — | 2 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200027 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL200027 | — | Inhibition | - | % | - |