Assay Detail
Toxicity
CHEMBL5715136
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Cytotoxicity against mouse FLC clone 745 cells assessed as reduction in cell viability measured after 48 hrs by Neubauer chamber based microscopic analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Mus musculus |
| Cell Type | FLC clone 745 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The histone methyltransferase inhibitor A-366 enhances hemoglobin expression in erythroleukemia cells upon co-exposure with chemical inducers in culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.42 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231795 | — | — | 1 | 6.36 |
| CHEMBL3414623 | — | — | 1 | 6.17 |
| CHEMBL2441082 | — | — | 1 | 5.80 |
| CHEMBL2204995 | — | — | 1 | 5.66 |
| CHEMBL5715246 | — | — | 1 | 5.64 |
| CHEMBL4544978 | — | — | 1 | 5.50 |
| CHEMBL3818617 | — | — | 1 | 5.33 |
| CHEMBL4072005 | — | — | 1 | 4.96 |
| CHEMBL3798846 | — | — | 1 | 4.75 |
| CHEMBL3414622 | — | — | 1 | 4.70 |
| CHEMBL4521971 | — | — | 1 | 4.70 |
| CHEMBL3109630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231795 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3414623 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2441082 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2204995 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5715246 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4544978 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3818617 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4072005 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3798846 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3414622 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4521971 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3109630 | — | IC50 | > | 100000.0 | nM | - |