Assay Detail
Binding
CHEMBL5716031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Itk using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter assay
3
Total Activities
3
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Itk inhibitors block T-cell activation and murine lung inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.91 | 7.72 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0005140 |
| EFO_ID | EFO_ID | - | — | HP:0002099 |
| EFO_TERM | EFO_TERM | - | — | autoimmune disease |
| EFO_TERM | EFO_TERM | - | — | asthma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209148 | — | — | 1 | 7.72 |
| CHEMBL382362 | — | — | 1 | 7.02 |
| CHEMBL205799 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209148 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL382362 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL205799 | — | IC50 | = | 1000.0 | nM | 6.00 |