Assay Detail
Binding
CHEMBL5716045
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Inhibition of PKC (unknown origin) using GST-SLP-76 as peptide substrate incubated for 10 mins in presence of [gamma-33P]ATP by scintillation counter assay
3
Total Activities
3
Compounds Tested
1
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Selective Itk inhibitors block T-cell activation and murine lung inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.65 | 4.68 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0005140 |
| EFO_ID | EFO_ID | - | — | HP:0002099 |
| EFO_TERM | EFO_TERM | - | — | autoimmune disease |
| EFO_TERM | EFO_TERM | - | — | asthma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382362 | — | — | 1 | 4.68 |
| CHEMBL209148 | — | — | 1 | 4.62 |
| CHEMBL205799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382362 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL209148 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL205799 | — | IC50 | > | 50000.0 | nM | - |