Assay Detail
Binding
CHEMBL5716488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin) using acetyl-Gly-Ala-(N-acetyl-Lys)-amino-4-methylcoumarin as substrate incubated for 15 mins by fluorescence plate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.08 | 8.30 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0015760 |
| EFO_TERM | EFO_TERM | - | — | t-cell non-hodgkin lymphoma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105727 | ABEXINOSTAT HYDROCHLORIDE | -1.0 | 1 | 8.30 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.55 |
| CHEMBL2170177 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105727 | ABEXINOSTAT HYDROCHLORIDE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2170177 | — | IC50 | = | 4000.0 | nM | 5.40 |