Assay Detail
Binding
CHEMBL5720225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length N-terminal GST-tagged CK1epsilon expressed in baculovirus infected Sf9 insect cells using casein as substrate measured after 60 mins by ADP-glo kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.62 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069623 | — | — | 1 | 8.13 |
| CHEMBL3948730 | UMBRALISIB | 4.0 | 1 | 5.22 |
| CHEMBL5722968 | — | — | 1 | 5.03 |
| CHEMBL5722975 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069623 | — | EC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3948730 | UMBRALISIB | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5722968 | — | EC50 | = | 9362.0 | nM | 5.03 |
| CHEMBL5722975 | — | EC50 | = | 81180.0 | nM | 4.09 |