Assay Detail

CHEMBL5721235

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Binding

Inhibition of EP4 (unknown origin)

ChEMBL ↗

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Target

Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗

Open DB target context

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Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin E2 receptor EP4 subtype

CHEMBL1836

Anchored from Assay target.

Protein identity Prostaglandin E2 receptor EP4 subtype

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Prostaglandin E2 receptor EP4 subtype (CHEMBL1836) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.
ACS Chem Biol (2017) 12 : 2619 -2630
PubMed 28849908 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.49	9.49

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL548	DINOPROSTONE	4.0	1	9.49

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL548	DINOPROSTONE	IC50	=	0.32	nM	9.49