Assay Detail

CHEMBL5721263

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of GABA (unknown origin)

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

GABA-A receptor; anion channel (CHEMBL2093872) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

GABA-A receptor; anion channel (CHEMBL2093872) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target GABA-A receptor; anion channel

CHEMBL2093872

Anchored from Assay target.

Protein identity GABA-A receptor; anion channel

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

GABA-A receptor; anion channel (CHEMBL2093872) ↗

Type	PROTEIN COMPLEX GROUP
Organism	Homo sapiens

Publication

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.
ACS Chem Biol (2017) 12 : 2619 -2630
PubMed 28849908 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.75	7.75

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL96	GAMMA-AMINOBUTYRIC ACID	1.0	1	7.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL96	GAMMA-AMINOBUTYRIC ACID	IC50	=	18.0	nM	7.75