Assay Detail

CHEMBL5721284

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Binding

Inhibition of H2 receptor (unknown origin)

ChEMBL ↗

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Target

Histamine H2 receptor (CHEMBL1941) ↗

Open DB target context

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Histamine H2 receptor (CHEMBL1941) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histamine H2 receptor

CHEMBL1941

Anchored from Assay target.

Protein identity Histamine H2 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histamine H2 receptor (CHEMBL1941) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.
ACS Chem Biol (2017) 12 : 2619 -2630
PubMed 28849908 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.28	6.28

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL30	CIMETIDINE	4.0	1	6.28

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL30	CIMETIDINE	IC50	=	530.0	nM	6.28