Assay Detail
Functional
CHEMBL5723299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity Biochemical interaction: (scintillation proximity assay, inhibition of radiolabelled [3H]cGMP substrate hydrolysis) EUB0002760aClOH PDE5A
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Category | Affinity biochemical assay |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Affinity Biochemical Literature for EUbOPEN Chemogenomic Library
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.15 | 9.15 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Mode of action | Mode of action | - | — | Inhibitor |
| Recommended concentration | Recommended concentration | 1.0 | uM | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5715931 | — | — | 1 | 9.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5715931 | — | IC50 | = | 0.7 | nM | 9.15 |