Assay Detail
Binding
CHEMBL5730503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PHENOSENSE assay: The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs).
6
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gag-Pol polyprotein (CHEMBL3638360) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) |
Publication
Methods of treating retroviral infections and related dosage regimes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.81 | 8.42 |
| kon | 2 | - | - |
| k_off | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | 2.0 | 3 | 8.42 |
| CHEMBL1538 | TENOFOVIR DISOPROXIL | 4.0 | 3 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515564 | TENOFOVIR EXALIDEX | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1538 | TENOFOVIR DISOPROXIL | IC50 | = | 6515.0 | nM | 5.19 |
| CHEMBL515564 | TENOFOVIR EXALIDEX | kon | = | - | — | - |
| CHEMBL515564 | TENOFOVIR EXALIDEX | k_off | = | - | s-1 | - |
| CHEMBL1538 | TENOFOVIR DISOPROXIL | kon | = | - | — | - |
| CHEMBL1538 | TENOFOVIR DISOPROXIL | k_off | = | - | s-1 | - |