Assay Detail
Binding
CHEMBL5730655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Broken Cell Assay: SLR080811, prepared as the HCl salt, was tested first at recombinant SphK1 and SphK2 using a broken cell assay.
6
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Long chain base sphingosine kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.96 | 7.00 |
| kon | 2 | - | - |
| k_off | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5825641 | — | — | 3 | 7.00 |
| CHEMBL3086782 | — | — | 3 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5825641 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3086782 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3086782 | — | kon | = | - | — | - |
| CHEMBL3086782 | — | k_off | = | - | s-1 | - |
| CHEMBL5825641 | — | kon | = | - | — | - |
| CHEMBL5825641 | — | k_off | = | - | s-1 | - |