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Assay Detail

CHEMBL5730970

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Dopamine D3 Receptor Binding Test: The experiment is carried out by the method according to Journal of Pharmacology and Experimental Therapeutics 2010, 333(1): 328. With [3H]methyl-spiperone (0.3 nM) as the ligand and (+)-butaclamol (10 LM) for determining non-specific binding, binding tests are carried out on human recombinant D3 receptor (expressed in CHO cells).
ChEMBL ↗
459
Total Activities
77
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Benzoisothiazole compounds and methods of treating schizophrenia
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 153 9.08 10.54
kon 153 - -
k_off 153 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3905247 — — 6 10.54
CHEMBL6016619 — — 6 10.46
CHEMBL3966842 — — 6 10.37
CHEMBL3976282 — — 6 10.25
CHEMBL3982486 — — 6 10.24
CHEMBL5792767 — — 6 10.21
CHEMBL5864883 — — 6 10.21
CHEMBL3896937 — — 6 10.17
CHEMBL5913523 — — 6 10.15
CHEMBL6052546 — — 6 10.11
CHEMBL5891297 — — 6 10.07
CHEMBL5845312 — — 6 10.06
CHEMBL5986307 — — 3 10.05
CHEMBL6010018 — — 6 10.03
CHEMBL5766303 — — 6 10.03
CHEMBL6065165 — — 6 10.00
CHEMBL5855446 — — 6 10.00
CHEMBL3946995 — — 6 9.89
CHEMBL3953773 — — 6 9.89
CHEMBL3940712 — — 6 9.74
CHEMBL5976918 — — 6 9.74
CHEMBL6029993 — — 6 9.72
CHEMBL5747372 — — 6 9.64
CHEMBL3950977 — — 6 9.60
CHEMBL3938210 — — 6 9.51
CHEMBL5909524 — — 6 9.43
CHEMBL3923240 — — 6 9.34
CHEMBL6025384 — — 6 9.24
CHEMBL5876989 — — 6 9.17
CHEMBL5967466 — — 6 9.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3905247 — Ki = 0.029 nM 10.54
CHEMBL3905247 — Ki = 0.029 nM 10.54
CHEMBL6016619 — Ki = 0.035 nM 10.46
CHEMBL6016619 — Ki = 0.035 nM 10.46
CHEMBL3966842 — Ki = 0.043 nM 10.37
CHEMBL3966842 — Ki = 0.043 nM 10.37
CHEMBL3976282 — Ki = 0.056 nM 10.25
CHEMBL3976282 — Ki = 0.056 nM 10.25
CHEMBL3982486 — Ki = 0.058 nM 10.24
CHEMBL3982486 — Ki = 0.058 nM 10.24
CHEMBL5864883 — Ki = 0.062 nM 10.21
CHEMBL5792767 — Ki = 0.061 nM 10.21
CHEMBL5792767 — Ki = 0.061 nM 10.21
CHEMBL5864883 — Ki = 0.062 nM 10.21
CHEMBL3896937 — Ki = 0.068 nM 10.17
CHEMBL3896937 — Ki = 0.068 nM 10.17
CHEMBL5913523 — Ki = 0.071 nM 10.15
CHEMBL5913523 — Ki = 0.071 nM 10.15
CHEMBL6052546 — Ki = 0.078 nM 10.11
CHEMBL6052546 — Ki = 0.078 nM 10.11
CHEMBL5891297 — Ki = 0.085 nM 10.07
CHEMBL5891297 — Ki = 0.085 nM 10.07
CHEMBL5845312 — Ki = 0.087 nM 10.06
CHEMBL5845312 — Ki = 0.087 nM 10.06
CHEMBL5986307 — Ki = 0.09 nM 10.05
CHEMBL6010018 — Ki = 0.093 nM 10.03
CHEMBL6010018 — Ki = 0.093 nM 10.03
CHEMBL5766303 — Ki = 0.093 nM 10.03
CHEMBL5766303 — Ki = 0.093 nM 10.03
CHEMBL6065165 — Ki = 0.1 nM 10.00
CHEMBL5855446 — Ki = 0.1 nM 10.00
CHEMBL6065165 — Ki = 0.1 nM 10.00
CHEMBL5855446 — Ki = 0.1 nM 10.00
CHEMBL3946995 — Ki = 0.13 nM 9.89
CHEMBL3946995 — Ki = 0.13 nM 9.89
CHEMBL3953773 — Ki = 0.13 nM 9.89
CHEMBL3953773 — Ki = 0.13 nM 9.89
CHEMBL3940712 — Ki = 0.18 nM 9.74
CHEMBL5976918 — Ki = 0.18 nM 9.74
CHEMBL5976918 — Ki = 0.18 nM 9.74
CHEMBL3940712 — Ki = 0.18 nM 9.74
CHEMBL6029993 — Ki = 0.19 nM 9.72
CHEMBL6029993 — Ki = 0.19 nM 9.72
CHEMBL5747372 — Ki = 0.23 nM 9.64
CHEMBL5747372 — Ki = 0.23 nM 9.64
CHEMBL3950977 — Ki = 0.25 nM 9.60
CHEMBL3950977 — Ki = 0.25 nM 9.60
CHEMBL3938210 — Ki = 0.31 nM 9.51
CHEMBL3938210 — Ki = 0.31 nM 9.51
CHEMBL5909524 — Ki = 0.37 nM 9.43