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Assay Detail

CHEMBL5731069

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
TBD: TBD
21
Total Activities
7
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

ALK tyrosine kinase receptor (CHEMBL4247)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protein tyrosine kinase modulators and methods of use
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 7.87 8.06
kon 7 - -
k_off 7 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6013504 3 8.06
CHEMBL5951162 3 8.03
CHEMBL5857101 3 7.96
CHEMBL5871879 3 7.92
CHEMBL5964556 3 7.82
CHEMBL5847006 3 7.77
CHEMBL5903567 3 7.55

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6013504 IC50 = 8.62 nM 8.06
CHEMBL5951162 IC50 = 9.33 nM 8.03
CHEMBL5857101 IC50 = 11.0 nM 7.96
CHEMBL5871879 IC50 = 12.0 nM 7.92
CHEMBL5964556 IC50 = 15.0 nM 7.82
CHEMBL5847006 IC50 = 17.0 nM 7.77
CHEMBL5903567 IC50 = 28.0 nM 7.55
CHEMBL5903567 kon = - -
CHEMBL5903567 k_off = - s-1 -
CHEMBL5871879 kon = - -
CHEMBL5871879 k_off = - s-1 -
CHEMBL5847006 kon = - -
CHEMBL5847006 k_off = - s-1 -
CHEMBL5951162 k_off = - s-1 -
CHEMBL5964556 kon = - -
CHEMBL5964556 k_off = - s-1 -
CHEMBL6013504 kon = - -
CHEMBL6013504 k_off = - s-1 -
CHEMBL5857101 kon = - -
CHEMBL5857101 k_off = - s-1 -
CHEMBL5951162 kon = - -