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Assay Detail

CHEMBL5731328

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Binding
Calcineurin Phosphatase (CaN) Assay: Enzo Life Sciences CaN Assay Kit: BML-AK8042x assay buffer: 100 mM Tris, pH7.5, 200 mM NaCl, 12 mM MgCl2, 1 mM DTT, 0.05% NP-40, 1 mM CaCl2
ChEMBL ↗
114
Total Activities
38
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 38 6.16 7.27
kon 38 - -
k_off 38 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5831332 — — 3 7.27
CHEMBL5990359 — — 3 7.12
CHEMBL6008494 — — 3 7.09
CHEMBL5814128 — — 3 6.89
CHEMBL5838709 — — 3 6.89
CHEMBL6031839 — — 3 6.76
CHEMBL5838537 — — 3 6.71
CHEMBL5823817 — — 3 6.70
CHEMBL160 CYCLOSPORINE 4.0 3 6.68
CHEMBL6058022 — — 3 6.65
CHEMBL5759995 — — 3 6.65
CHEMBL5793610 — — 3 6.64
CHEMBL6044933 — — 3 6.60
CHEMBL5773015 — — 3 6.52
CHEMBL5795040 — — 3 6.52
CHEMBL5849641 — — 3 6.52
CHEMBL5959943 — — 3 6.49
CHEMBL5973986 — — 3 6.49
CHEMBL5853026 — — 3 6.49
CHEMBL5896835 — — 3 6.46
CHEMBL5954044 — — 3 6.42
CHEMBL5906552 — — 3 6.42
CHEMBL6018012 — — 3 6.40
CHEMBL6025739 — — 3 6.37
CHEMBL5869516 — — 3 6.34
CHEMBL5896179 — — 3 6.32
CHEMBL5746804 — — 3 6.19
CHEMBL6035639 — — 3 5.40
CHEMBL5781176 — — 3 5.00
CHEMBL5935219 — — 3 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5831332 — IC50 = 53.5 nM 7.27
CHEMBL5990359 — IC50 = 76.5 nM 7.12
CHEMBL6008494 — IC50 = 80.5 nM 7.09
CHEMBL5838709 — IC50 = 130.0 nM 6.89
CHEMBL5814128 — IC50 = 128.0 nM 6.89
CHEMBL6031839 — IC50 = 172.0 nM 6.76
CHEMBL5838537 — IC50 = 196.0 nM 6.71
CHEMBL5823817 — IC50 = 200.0 nM 6.70
CHEMBL160 CYCLOSPORINE IC50 = 210.0 nM 6.68
CHEMBL6058022 — IC50 = 226.0 nM 6.65
CHEMBL5759995 — IC50 = 226.0 nM 6.65
CHEMBL5793610 — IC50 = 230.0 nM 6.64
CHEMBL6044933 — IC50 = 251.0 nM 6.60
CHEMBL5849641 — IC50 = 304.0 nM 6.52
CHEMBL5795040 — IC50 = 300.0 nM 6.52
CHEMBL5773015 — IC50 = 300.0 nM 6.52
CHEMBL5973986 — IC50 = 327.0 nM 6.49
CHEMBL5959943 — IC50 = 326.0 nM 6.49
CHEMBL5853026 — IC50 = 322.0 nM 6.49
CHEMBL5896835 — IC50 = 351.0 nM 6.46
CHEMBL5954044 — IC50 = 377.0 nM 6.42
CHEMBL5906552 — IC50 = 379.0 nM 6.42
CHEMBL6018012 — IC50 = 402.0 nM 6.40
CHEMBL6025739 — IC50 = 428.0 nM 6.37
CHEMBL5869516 — IC50 = 453.0 nM 6.34
CHEMBL5896179 — IC50 = 476.0 nM 6.32
CHEMBL5746804 — IC50 = 650.0 nM 6.19
CHEMBL6035639 — IC50 = 4000.0 nM 5.40
CHEMBL5881660 — IC50 = 10000.0 nM 5.00
CHEMBL5842028 — IC50 = 10000.0 nM 5.00
CHEMBL5954246 — IC50 = 10000.0 nM 5.00
CHEMBL6027763 — IC50 = 10000.0 nM 5.00
CHEMBL5781176 — IC50 = 10000.0 nM 5.00
CHEMBL5785207 — IC50 = 10000.0 nM 5.00
CHEMBL5942804 — IC50 = 10000.0 nM 5.00
CHEMBL5920562 — IC50 = 10000.0 nM 5.00
CHEMBL5935219 — IC50 = 10000.0 nM 5.00
CHEMBL6001218 — IC50 = 10000.0 nM 5.00
CHEMBL6058022 — k_off = - s-1 -
CHEMBL6027763 — k_off = - s-1 -
CHEMBL6027763 — kon = - — -
CHEMBL5793610 — k_off = - s-1 -
CHEMBL5793610 — kon = - — -
CHEMBL5746804 — k_off = - s-1 -
CHEMBL5746804 — kon = - — -
CHEMBL6031839 — k_off = - s-1 -
CHEMBL6031839 — kon = - — -
CHEMBL5853026 — kon = - — -
CHEMBL5853026 — k_off = - s-1 -
CHEMBL5959943 — kon = - — -