Assay Detail
Binding
CHEMBL5731494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ALK IR Anaplastic Lymphoma Kinase Activity: To measure the activity of the N2-(2-methoxyphenyl)pyrimidine derivative represented by formula 1 of the present invention to inhibit anaplastic lymphoma kinase (ALK) activity at enzyme level, the following experiment was performed by the same manner as described in experimental example 1 except that IR (Insulin Receptor) protein was used instead of ALK WT protein.
159
Total Activities
53
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N2-(2-methoxyphenyl)pyrimidine derivative, method for preparing same, and pharmaceutical composition for cancer prevention or treatment containing same as active ingredient
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 7.59 | 8.74 |
| kon | 53 | - | - |
| k_off | 53 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081656 | — | — | 3 | 8.74 |
| CHEMBL4078406 | — | — | 3 | 8.72 |
| CHEMBL5990800 | — | — | 3 | 8.68 |
| CHEMBL5907234 | — | — | 3 | 8.64 |
| CHEMBL4099660 | — | — | 3 | 8.64 |
| CHEMBL4080869 | — | — | 3 | 8.59 |
| CHEMBL4084168 | — | — | 3 | 8.59 |
| CHEMBL4062466 | — | — | 3 | 8.49 |
| CHEMBL5764344 | — | — | 3 | 8.46 |
| CHEMBL4091928 | — | — | 3 | 8.46 |
| CHEMBL4067503 | — | — | 3 | 8.42 |
| CHEMBL4089672 | — | — | 3 | 8.41 |
| CHEMBL4097392 | — | — | 3 | 8.32 |
| CHEMBL4070217 | — | — | 3 | 8.24 |
| CHEMBL4088751 | — | — | 3 | 8.22 |
| CHEMBL4105099 | — | — | 3 | 8.22 |
| CHEMBL4096452 | — | — | 3 | 8.21 |
| CHEMBL5804159 | — | — | 3 | 8.00 |
| CHEMBL5831597 | — | — | 3 | 8.00 |
| CHEMBL5757765 | — | — | 3 | 8.00 |
| CHEMBL6030742 | — | — | 3 | 8.00 |
| CHEMBL5812517 | — | — | 3 | 8.00 |
| CHEMBL5957476 | — | — | 3 | 8.00 |
| CHEMBL4071105 | — | — | 3 | 7.77 |
| CHEMBL4061549 | — | — | 3 | 7.75 |
| CHEMBL5916115 | — | — | 3 | 7.70 |
| CHEMBL5864674 | — | — | 3 | 7.70 |
| CHEMBL5835139 | — | — | 3 | 7.70 |
| CHEMBL6047646 | — | — | 3 | 7.70 |
| CHEMBL6006760 | — | — | 3 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081656 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4078406 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5990800 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4099660 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5907234 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4080869 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4084168 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4062466 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5764344 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4091928 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4067503 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4089672 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4097392 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4070217 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4088751 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4105099 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4096452 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5812517 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5757765 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5831597 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5957476 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5804159 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL6030742 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4071105 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4061549 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5864674 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5835139 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL6047646 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL6006760 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5916115 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5742478 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5947897 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5751408 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5780443 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5983550 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5872198 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL6052776 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5881889 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5748068 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5895722 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL6014384 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5790566 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4089527 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5861896 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL6011332 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5997057 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4061375 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5846140 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5773764 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5775962 | — | IC50 | = | 1700.0 | nM | 5.77 |