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Assay Detail

CHEMBL5732764

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Binding
CPE Inhibitory Effect Confirming Assay: A test sample was diluted with a culture medium to an appropriate concentration in advance, and then 2 to 5-fold serial dilution on a 96 well plate (50 μL/well) was prepared. Two plates, one for measuring anti-Flu activity and the another for measuring cytotoxity, were prepared. Each assay was performed triplicate for each drug.At the use of MDCK cells, Trypsin was added to the cells to be a final concentration of 3 μg/mL only for measuring anti-Flu activity.
ChEMBL ↗
2352
Total Activities
388
Compounds Tested
4
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Substituted polycyclic carbamoyl pyridone derivative prodrug
(2019)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
kon 784 - -
k_off 784 - -
IC50 392 7.19 8.60
EC50 392 7.29 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5754703 — — 6 9.10
CHEMBL5803214 — — 6 9.00
CHEMBL5900492 — — 6 8.70
CHEMBL6019289 — — 6 8.68
CHEMBL5954632 — — 6 8.59
CHEMBL4761134 — — 6 8.52
CHEMBL4760987 — — 6 8.52
CHEMBL5955219 — — 6 8.52
CHEMBL5850099 — — 6 8.52
CHEMBL6020777 — — 6 8.52
CHEMBL5891729 — — 6 8.51
CHEMBL6000586 — — 6 8.47
CHEMBL5952314 — — 6 8.46
CHEMBL5808102 — — 6 8.46
CHEMBL5951781 — — 6 8.46
CHEMBL5889439 — — 6 8.44
CHEMBL5827263 — — 6 8.44
CHEMBL5760114 — — 6 8.43
CHEMBL5814035 — — 6 8.43
CHEMBL5790991 — — 6 8.42
CHEMBL5740597 — — 18 8.42
CHEMBL5876746 — — 6 8.40
CHEMBL4758004 — — 6 8.40
CHEMBL4763145 — — 6 8.40
CHEMBL4761936 — — 6 8.40
CHEMBL4778542 — — 6 8.40
CHEMBL5791845 — — 6 8.40
CHEMBL5850594 — — 6 8.40
CHEMBL5739934 — — 6 8.40
CHEMBL6014611 — — 6 8.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5754703 — EC50 = 0.799 nM 9.10
CHEMBL5803214 — EC50 = 1.0 nM 9.00
CHEMBL5900492 — EC50 = 2.0 nM 8.70
CHEMBL6019289 — EC50 = 2.08 nM 8.68
CHEMBL5754703 — IC50 = 2.52 nM 8.60
CHEMBL5954632 — IC50 = 2.6 nM 8.59
CHEMBL5955219 — EC50 = 3.0 nM 8.52
CHEMBL6020777 — EC50 = 3.05 nM 8.52
CHEMBL5850099 — EC50 = 3.0 nM 8.52
CHEMBL4761134 — EC50 = 3.0 nM 8.52
CHEMBL4760987 — EC50 = 3.0 nM 8.52
CHEMBL5891729 — EC50 = 3.12 nM 8.51
CHEMBL6000586 — IC50 = 3.36 nM 8.47
CHEMBL5951781 — EC50 = 3.51 nM 8.46
CHEMBL5808102 — EC50 = 3.5 nM 8.46
CHEMBL5952314 — EC50 = 3.5 nM 8.46
CHEMBL5827263 — EC50 = 3.64 nM 8.44
CHEMBL5889439 — IC50 = 3.67 nM 8.44
CHEMBL5814035 — EC50 = 3.68 nM 8.43
CHEMBL5760114 — IC50 = 3.74 nM 8.43
CHEMBL5790991 — EC50 = 3.84 nM 8.42
CHEMBL5740597 — EC50 = 3.78 nM 8.42
CHEMBL6000586 — EC50 = 3.91 nM 8.41
CHEMBL5760114 — EC50 = 3.93 nM 8.41
CHEMBL5740597 — EC50 = 3.95 nM 8.40
CHEMBL4758004 — EC50 = 4.0 nM 8.40
CHEMBL4763145 — EC50 = 4.0 nM 8.40
CHEMBL5876746 — EC50 = 4.0 nM 8.40
CHEMBL4761936 — EC50 = 4.0 nM 8.40
CHEMBL5739934 — EC50 = 4.0 nM 8.40
CHEMBL5850594 — EC50 = 4.0 nM 8.40
CHEMBL5791845 — EC50 = 4.0 nM 8.40
CHEMBL4778542 — EC50 = 4.0 nM 8.40
CHEMBL6014611 — EC50 = 4.05 nM 8.39
CHEMBL5889439 — EC50 = 4.05 nM 8.39
CHEMBL4798466 — EC50 = 4.28 nM 8.37
CHEMBL6052829 — EC50 = 4.32 nM 8.37
CHEMBL5798645 — EC50 = 5.0 nM 8.30
CHEMBL5935738 — EC50 = 5.0 nM 8.30
CHEMBL5848247 — EC50 = 5.0 nM 8.30
CHEMBL4763708 — EC50 = 5.0 nM 8.30
CHEMBL5768383 — IC50 = 5.0 nM 8.30
CHEMBL5739934 — IC50 = 5.0 nM 8.30
CHEMBL6006399 — EC50 = 5.0 nM 8.30
CHEMBL4103104 — EC50 = 5.0 nM 8.30
CHEMBL5966658 — IC50 = 5.07 nM 8.29
CHEMBL5814035 — IC50 = 5.22 nM 8.28
CHEMBL5757918 — IC50 = 5.54 nM 8.26
CHEMBL5757918 — EC50 = 5.6 nM 8.25
CHEMBL4798466 — IC50 = 5.57 nM 8.25