Assay Detail
Binding
CHEMBL5733346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
High-Throughput Assay: Please see Hutti, et al., (2012). Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε.
15
Total Activities
5
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Assays for screening for or identifying an agent or molecule that can block or inhibit AVB3 integrin from forming a complex with KRAS
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.11 | 6.11 |
| kon | 5 | - | - |
| k_off | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1485263 | — | — | 3 | 6.11 |
| CHEMBL5821044 | — | — | 3 | - |
| CHEMBL582653 | — | — | 3 | - |
| CHEMBL5887199 | — | — | 3 | - |
| CHEMBL5876728 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1485263 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1485263 | — | kon | = | - | — | - |
| CHEMBL1485263 | — | k_off | = | - | s-1 | - |
| CHEMBL5821044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5821044 | — | kon | = | - | — | - |
| CHEMBL5821044 | — | k_off | = | - | s-1 | - |
| CHEMBL582653 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL582653 | — | kon | = | - | — | - |
| CHEMBL582653 | — | k_off | = | - | s-1 | - |
| CHEMBL5887199 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5887199 | — | kon | = | - | — | - |
| CHEMBL5887199 | — | k_off | = | - | s-1 | - |
| CHEMBL5876728 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5876728 | — | kon | = | - | — | - |
| CHEMBL5876728 | — | k_off | = | - | s-1 | - |