Assay Detail
Binding
CHEMBL5733631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Determination of Binding Constants of HITS to TTR: Dissociation Constants (Kd) associated with the binding of ligands to TTR are expressed in nM. Thermodynamic Binding Parameters associated with ligand binding to TTR; Binding free energies (ΔG), enthalpies (ΔH), and binding entropies (TΔS) values are reported in units of kcal mol−1.
24
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of stabilizers of multimeric proteins
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.54 | 7.14 |
| kon | 8 | - | - |
| k_off | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122055 | — | — | 3 | 7.14 |
| CHEMBL1256291 | — | — | 3 | 6.74 |
| CHEMBL3695463 | — | — | 3 | 6.61 |
| CHEMBL5769571 | — | — | 3 | 6.54 |
| CHEMBL3695460 | — | — | 3 | 6.50 |
| CHEMBL3695468 | — | — | 3 | 6.43 |
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 3 | 6.23 |
| CHEMBL5945002 | — | — | 3 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122055 | — | Kd | = | 72.5 | nM | 7.14 |
| CHEMBL1256291 | — | Kd | = | 184.0 | nM | 6.74 |
| CHEMBL3695463 | — | Kd | = | 245.0 | nM | 6.61 |
| CHEMBL5769571 | — | Kd | = | 285.0 | nM | 6.54 |
| CHEMBL3695460 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL3695468 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL63323 | NIFLUMIC ACID | Kd | = | 592.0 | nM | 6.23 |
| CHEMBL5945002 | — | Kd | = | 820.0 | nM | 6.09 |
| CHEMBL5769571 | — | kon | = | - | — | - |
| CHEMBL5769571 | — | k_off | = | - | s-1 | - |
| CHEMBL5945002 | — | kon | = | - | — | - |
| CHEMBL5945002 | — | k_off | = | - | s-1 | - |
| CHEMBL122055 | — | kon | = | - | — | - |
| CHEMBL122055 | — | k_off | = | - | s-1 | - |
| CHEMBL3695460 | — | kon | = | - | — | - |
| CHEMBL3695460 | — | k_off | = | - | s-1 | - |
| CHEMBL1256291 | — | kon | = | - | — | - |
| CHEMBL1256291 | — | k_off | = | - | s-1 | - |
| CHEMBL3695463 | — | kon | = | - | — | - |
| CHEMBL3695463 | — | k_off | = | - | s-1 | - |
| CHEMBL63323 | NIFLUMIC ACID | kon | = | - | — | - |
| CHEMBL63323 | NIFLUMIC ACID | k_off | = | - | s-1 | - |
| CHEMBL3695468 | — | kon | = | - | — | - |
| CHEMBL3695468 | — | k_off | = | - | s-1 | - |