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Assay Detail

CHEMBL5733718

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Recombinant Enzyme Assay: No preinc (Column 4).
ChEMBL ↗
1185
Total Activities
393
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glutaminase kidney isoform, mitochondrial (CHEMBL2146302) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Heterocyclic inhibitors of glutaminase
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 395 6.09 7.31
kon 395 - -
k_off 395 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3670049 — — 3 7.31
CHEMBL5890092 — — 3 7.25
CHEMBL3669995 — — 3 7.24
CHEMBL3670033 — — 3 7.21
CHEMBL5811126 — — 3 7.19
CHEMBL3670034 — — 3 7.17
CHEMBL3670048 — — 3 7.16
CHEMBL5837584 — — 3 7.14
CHEMBL3670063 — — 3 7.13
CHEMBL3670035 — — 3 7.12
CHEMBL3670004 — — 3 7.10
CHEMBL3670046 — — 3 7.10
CHEMBL3669983 — — 3 7.09
CHEMBL3674970 — — 3 7.09
CHEMBL3670009 — — 3 7.08
CHEMBL3674969 — — 3 7.07
CHEMBL3674972 — — 3 7.07
CHEMBL3670062 — — 3 7.04
CHEMBL3680029 — — 3 7.02
CHEMBL3670075 — — 3 7.01
CHEMBL3669972 — — 3 7.00
CHEMBL3669996 — — 3 7.00
CHEMBL6011756 — — 3 7.00
CHEMBL3670050 — — 3 7.00
CHEMBL3670051 — — 3 7.00
CHEMBL3674968 — — 3 7.00
CHEMBL3669870 — — 3 6.96
CHEMBL3669938 — — 3 6.96
CHEMBL5744207 — — 3 6.96
CHEMBL3670008 — — 3 6.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3670049 — IC50 = 49.0 nM 7.31
CHEMBL5890092 — IC50 = 56.0 nM 7.25
CHEMBL3669995 — IC50 = 57.0 nM 7.24
CHEMBL3670033 — IC50 = 62.0 nM 7.21
CHEMBL5811126 — IC50 = 65.0 nM 7.19
CHEMBL3670034 — IC50 = 68.0 nM 7.17
CHEMBL3670048 — IC50 = 69.0 nM 7.16
CHEMBL5837584 — IC50 = 72.0 nM 7.14
CHEMBL3670063 — IC50 = 74.0 nM 7.13
CHEMBL3670035 — IC50 = 76.0 nM 7.12
CHEMBL3670004 — IC50 = 80.0 nM 7.10
CHEMBL3670046 — IC50 = 79.0 nM 7.10
CHEMBL3669983 — IC50 = 82.0 nM 7.09
CHEMBL3674970 — IC50 = 81.0 nM 7.09
CHEMBL3670009 — IC50 = 83.0 nM 7.08
CHEMBL3674969 — IC50 = 86.0 nM 7.07
CHEMBL3674972 — IC50 = 85.0 nM 7.07
CHEMBL3670062 — IC50 = 92.0 nM 7.04
CHEMBL3680029 — IC50 = 96.0 nM 7.02
CHEMBL3670075 — IC50 = 97.0 nM 7.01
CHEMBL3669972 — IC50 = 100.0 nM 7.00
CHEMBL3674968 — IC50 = 99.0 nM 7.00
CHEMBL3670051 — IC50 = 100.0 nM 7.00
CHEMBL3669996 — IC50 = 100.0 nM 7.00
CHEMBL6011756 — IC50 = 100.0 nM 7.00
CHEMBL3670050 — IC50 = 100.0 nM 7.00
CHEMBL3669938 — IC50 = 110.0 nM 6.96
CHEMBL3670065 — IC50 = 110.0 nM 6.96
CHEMBL5744207 — IC50 = 110.0 nM 6.96
CHEMBL3669870 — IC50 = 110.0 nM 6.96
CHEMBL5998766 — IC50 = 110.0 nM 6.96
CHEMBL3670008 — IC50 = 110.0 nM 6.96
CHEMBL5971374 — IC50 = 120.0 nM 6.92
CHEMBL3670042 — IC50 = 120.0 nM 6.92
CHEMBL3670014 — IC50 = 120.0 nM 6.92
CHEMBL6015078 — IC50 = 120.0 nM 6.92
CHEMBL3669992 — IC50 = 120.0 nM 6.92
CHEMBL3669867 — IC50 = 120.0 nM 6.92
CHEMBL3670064 — IC50 = 120.0 nM 6.92
CHEMBL3670076 — IC50 = 120.0 nM 6.92
CHEMBL6026501 — IC50 = 120.0 nM 6.92
CHEMBL3680030 — IC50 = 120.0 nM 6.92
CHEMBL5746248 — IC50 = 120.0 nM 6.92
CHEMBL3669906 — IC50 = 120.0 nM 6.92
CHEMBL3669874 — IC50 = 130.0 nM 6.89
CHEMBL3670038 — IC50 = 130.0 nM 6.89
CHEMBL3670043 — IC50 = 130.0 nM 6.89
CHEMBL3669974 — IC50 = 140.0 nM 6.85
CHEMBL6056981 — IC50 = 140.0 nM 6.85
CHEMBL3670013 — IC50 = 140.0 nM 6.85