Assay Detail
Binding
CHEMBL5733769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity Assay: HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step to −60 mV (to obtain an estimate of leak), a 100 ms step back to −70 mV, a 1 s step to +40 mV, a 2 s step to −30 mV, and finally a 500 ms step to −70 mV. In between the pre- and post-compound voltage pulses, there was no clamping of the membrane potential. Currents were leak-subtracted based on the estimate of current evoked during the +10 mV step at the start of the voltage pulse protocol. The current signal was sampled at 2.5 k Hz. For each compound, the IC50 value was determined.
348
Total Activities
108
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibiting neurotransmitter reuptake
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 116 | 4.93 | 6.33 |
| kon | 116 | - | - |
| k_off | 116 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 3 | 6.33 |
| CHEMBL6049222 | — | — | 3 | 6.07 |
| CHEMBL5954657 | — | — | 3 | 5.80 |
| CHEMBL5849289 | — | — | 3 | 5.68 |
| CHEMBL5831041 | — | — | 3 | 5.66 |
| CHEMBL5904229 | — | — | 3 | 5.52 |
| CHEMBL5995318 | — | — | 3 | 5.51 |
| CHEMBL5854009 | — | — | 3 | 5.51 |
| CHEMBL5748389 | — | — | 3 | 5.48 |
| CHEMBL6055278 | — | — | 3 | 5.42 |
| CHEMBL5875051 | — | — | 3 | 5.42 |
| CHEMBL5978682 | — | — | 3 | 5.39 |
| CHEMBL6003284 | — | — | 3 | 5.39 |
| CHEMBL6063379 | — | — | 3 | 5.39 |
| CHEMBL5756427 | — | — | 3 | 5.37 |
| CHEMBL5994098 | — | — | 3 | 5.36 |
| CHEMBL5809105 | — | — | 3 | 5.35 |
| CHEMBL5981380 | — | — | 3 | 5.34 |
| CHEMBL5982233 | — | — | 3 | 5.33 |
| CHEMBL5769554 | — | — | 6 | 5.33 |
| CHEMBL6010382 | — | — | 3 | 5.33 |
| CHEMBL6005366 | — | — | 3 | 5.32 |
| CHEMBL5989415 | — | — | 3 | 5.30 |
| CHEMBL6011637 | — | — | 3 | 5.27 |
| CHEMBL490 | PAROXETINE | 4.0 | 3 | 5.27 |
| CHEMBL5769402 | — | — | 6 | 5.21 |
| CHEMBL5893791 | — | — | 6 | 5.21 |
| CHEMBL5877069 | — | — | 3 | 5.21 |
| CHEMBL5954037 | — | — | 3 | 5.21 |
| CHEMBL5919524 | — | — | 3 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL6049222 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5954657 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5849289 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5831041 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5904229 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5995318 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5854009 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5748389 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL6055278 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5875051 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL6063379 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL6003284 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5978682 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5756427 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5994098 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5809105 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5981380 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5769554 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5769554 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5982233 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL6010382 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL6005366 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5989415 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL6011637 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL490 | PAROXETINE | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5893791 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5877069 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5769402 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL5954037 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5919524 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL5992117 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL5839575 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5882181 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5925065 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL6048577 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5769402 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL5865081 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5955713 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL5893791 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5969329 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4227444 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL5915068 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5929452 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5877282 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL5994278 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5817730 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5924087 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5838051 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5796076 | — | IC50 | = | 11000.0 | nM | 4.96 |