Assay Detail
Binding
CHEMBL5733989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Omnia Assay: ITK: This example describes continuous-read kinase assays to measure inherent potency of compound against active forms of ITK enzymes as described in Example 251 above except that the modified ITK-optimized reagent conditions are:[ITK]=10 nM, [ATP]=25 [Y6-Sox]=10 μM (ATP KMapp=33 μM).
429
Total Activities
140
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Substituted 2,4-diaminopyrimidines as kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 143 | 6.99 | 7.26 |
| kon | 143 | - | - |
| k_off | 143 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6033285 | — | — | 3 | 7.26 |
| CHEMBL5942546 | — | — | 3 | 7.26 |
| CHEMBL5759845 | — | — | 3 | 7.26 |
| CHEMBL6052028 | — | — | 3 | 7.26 |
| CHEMBL5741005 | — | — | 3 | 7.26 |
| CHEMBL6039812 | — | — | 3 | 7.26 |
| CHEMBL6025850 | — | — | 3 | 7.26 |
| CHEMBL5954027 | — | — | 3 | 7.26 |
| CHEMBL6014788 | — | — | 3 | 7.26 |
| CHEMBL5833997 | — | — | 3 | 7.26 |
| CHEMBL6056251 | — | — | 3 | 7.26 |
| CHEMBL5763010 | — | — | 3 | 7.26 |
| CHEMBL5773640 | — | — | 3 | 7.26 |
| CHEMBL6044013 | — | — | 3 | 7.26 |
| CHEMBL6022830 | — | — | 6 | 7.26 |
| CHEMBL6013487 | — | — | 3 | 7.26 |
| CHEMBL5746419 | — | — | 3 | 7.26 |
| CHEMBL5939316 | — | — | 3 | 7.26 |
| CHEMBL5995813 | — | — | 3 | 7.26 |
| CHEMBL6025324 | — | — | 3 | 7.26 |
| CHEMBL5950512 | — | — | 3 | 7.26 |
| CHEMBL5948101 | — | — | 3 | 7.26 |
| CHEMBL5900800 | — | — | 3 | 7.26 |
| CHEMBL5747706 | — | — | 3 | 7.26 |
| CHEMBL5756489 | — | — | 3 | 7.26 |
| CHEMBL5795317 | — | — | 3 | 7.26 |
| CHEMBL5798780 | — | — | 3 | 7.26 |
| CHEMBL5791105 | — | — | 3 | 7.26 |
| CHEMBL5780712 | — | — | 3 | 7.26 |
| CHEMBL5764023 | — | — | 3 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5773640 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5821130 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5892354 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6022830 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5900800 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5891594 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5747706 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5808700 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5891594 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5756489 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5780633 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5791105 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5985220 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6033285 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5780712 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5916856 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6040634 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5763010 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6056251 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5752981 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6013487 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5797771 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5940517 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5741005 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6052028 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5970361 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5822224 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5918405 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6025324 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5858035 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5950214 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5950512 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5954027 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5740925 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6003257 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5942546 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5995813 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5939316 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5759845 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6014788 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5922445 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5933081 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5825514 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL3301625 | SPEBRUTINIB | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5836521 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL6041177 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5746419 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5833997 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5948101 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5932966 | — | IC50 | = | 55.0 | nM | 7.26 |